By Henry L. Nadler (auth.), Harry Harris, Kurt Hirschhorn (eds.)
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Metab. 33: 683 (1962). 11. Spackman, D. , Technicon Monograph No. 3, Geneva, p. 40, 1968. 12. Levy, H. L. and P. P. Montag, Free amino acids in human amniotic fluid, A quantitative study by ion-exchange chromatography, Pediat. Res. 3: 113 (1969). 30 Henry L. Nadler 13. Emery, A. E. , D. Burt, J. B. Scrimgeour, and M. M. Nelson, Antenatal diagnosis and amino acid composition of amniotic fluid, Lancet 1: 1307 (1970). 14. , III, R. H. Schwarz, J. A. A. Barness, Prenatal detection of methylmalonic acidemia, J.
141 Since the demonstration of its value in the management of Rh isoimmunization, the technique of transabdominal amniocentesis has gained widespread acceptance. 142 •143 This procedure has been performed over 20,000 times after the twentieth week of pregnancy and maternal or fetal morbidity or mortality reported in less than 1% of cases. 147 •149 •150 The maternal morbidity includes amnionitis, maternal hemorrhage, abdominal pain, and peritonitis. More recently transabdominal amniocentesis has been performed early in the second trimester of pregnancy.
Bigley, and G. Hug, Prenatal detection of Pompe's disease, Lancet 11: 369 (1970). 60. , A. Dorfman, H. L. Nadler, and C. B. Jacobson, A chemical method for the prenatal diagnosis of mucopolysaccharides, Lancet 1: 83 (1970). 61. , H. Jacoby, and D. Charles, Exfoliative cytology of amniotic fluid, Acta Cytol. 9: 442 (1965). 62. Huisjes, H. , Origin of the cells in the liquor amnii, Am. J. Obstet. Gynec. 106: 1222 (1970). 63. , and P. Riis, Antenatal sex determination, Nature 177: 330 (1956). 64. Shettles, L.